Robert Cudmore

Robert H Cudmore Robert H. Cudmore, PhD
Research Associate

Linden Lab, Department of Neuroscience
The Johns Hopkins University
School of Medicine

Email:

Research Interests

My research is focused on understanding how experience, disease and aging can alter the structure and function of the brain.

I do this using time-lapse in vivo two-photon imaging in mice with genetically encoded fluorescent markers to visualize both neuronal and vascular structures. This is a powerful technique as it allows the living brain to be repeatedly imaged at a micro-meter scale over a wide range of time scales from seconds and minutes to weeks and months.

News

2017 - My work examining vascular and pericyte plasticity in response to exercise was published in The Journal of Cerebral Blood Flow and Metabolism (2017).

2016 - I was awarded a 4-year (2016-2020) Scientist Development Grant from the American Heart Association to examine structural and functional changes in cerebral vasculature following ischemic stroke.

2016 - Our work on serotonergic axon regeneration was published in Neuron (2016).

2015 - My work on experience dependent plasticity of surface AMPA receptor expression was published in
Nature Neuroscience (2015).

Software

To make these experiments possible, I have developed Map Manager to analyze and track 3D structures (spines, boutons and vasculature) in 3D image volume time-series. In addition, I have designed on-the-scope instrumentation including a spatial image acquisition canvas and a motorized treadmill with synchronized video to be used during awake in vivo two-photon imaging.

Dept. of Neuroscience, Linden Lab Johns Hopkins Medicine © 2008-2018